Biochemical reductions aromatic ketones

Hemker was one of the first to attempt the quantitative correlation of biochemical response using both partition coefficients and ionization constants to account for the uncoupling action of phenols. The linear combination of it and o has been found to hold for several enzymic reactions > as well as the binding of phenols by protein , the toxicity of phenols , the uncoupling action of phenols , and the relative sweetness of nitroanilines . An interesting application is that of McMahon . Equation 14 was formulated for the enzymic reduction of aromatic ketones to alcohols. 

Stout DM, Meyers AI (1982) Recent advances in the chemistry of dihydropyridines. Chem Rev 82 223-243 Siidi J (1976) Chiral recognition of prochiral centers and general acid-base catalysis. Biochem J 153 491-493 Sugimoto T, Matsumura Y, Tanimoto S, Okano M (1978) Asymmetric reduction of aromatic ketones by sodium borohydride in the presence of bovine serum albumin. J Chem Soc Chem Commun 926-927 Sugimoto T, Kokubo T, Miyazaki J, Tanimoto S, Okano M (1979a)... 

Asymmetric reduction of prochiral diaryl ketones (33 34, Scheme 12) is an important chemical transformation due to the practical significance of the resulting diaryl methanol derivatives 34 for biochemical and pharmaceutical applications [24]. It is also a challenging problem due to the lack of sufficient stereochemical bias between the two aromatic groups and coupled with a lower reactivity of diaryl ketones compared to the related aryl alkyl analogues. Chan reported catalytic... 

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