Biochemical engineering process modeling

We revisit the different types of models which are essential in model development for the different chemical/biochemical engineering processes. Batch processes are usually of the isolated- or closed-system type, whereas the continuous processes are almost always of the open-system type. 

Mathematical modelling, in biochemical engineering, 77 41 Mathematical models of glass melting, 72 605 process-control, 20 687-691 Mathematical optimization approach, in computer- aided molecular design, 26 1037... 

Kusic, H Koprivanac, N Loncaric Bozic, A Papic, S Petemel, I Vujevic, D. Reactive dye degradation by a photochemical AOP - development of a kinetic model for UV/H2O2 process. Chemical and Biochemical Engineering Quarterly, 2006 in press. 

Ion transport is also often coupled with cellular energy production and with nutrient and product membrane transport. Aside from Papoutsakis work on the influence of methanol transport on growth of methanol-consuming bacteria, the importance of membrane control of nutrient and product fluxes into the cell has been largely ignored by biochemical engineers [25]. Better methods for measuring the pH and electrical potential differences across cell membranes are needed, as is more careful consideration of membrane-mediated processes in cell kinetics models. 

To date, biochemical engineers have concentrated heavily on modeling and analysis of the enzyme synthesis process and have almost completely ignored the enzyme decomposition processes which are important in many... 

Before the era of modern computers, the EVOP process investigation was used successfully to improve the efficiency of many chemical engineering processes. Now its use is receding due to the competition from process mathematical modelling and simulation. However, biochemical and life processes are two large domains where the use of the EVOP investigation can still bring spectacular results. 

Because of their predictive capabilities, models are also essential tools in modem biochemical engineering for the design of processes and the optimization of media and reactor operational parameters in batch or continuous operation. They can also serve in the development of software sensors to estimate on-line the time variation of the medium composition. 

By adopting a system approach, the book deals with a wide range of subjects normally covered in a number of separate courses— mass and energy balances, transport phenomena, chemical reaction engineering, mathematical modeling, and process control. Students are thus enabled to address problems concerning physical systems, chemical reactors, and biochemical processes (in which microbial growth and enzymes play key roles). 

Process Biochemistry. 1966-. Amsterdam Elsevier (1359-5113). Online ScienceDirect. Main topics covered are fermentation, biochemical and bioreactor engineering, biotechnology processes and their life science aspects, biocatalysts, enzyme engineering and biotransformation, downstream processing, modeling, optimization, and control techniques. 

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