Bioavailability gastrointestinal absorption

One particular feature of plant-derived cannabinoids is their high lipid solubility, which indicates that limited gastrointestinal absorption and bioavailability are significant barriers to their development as therapeutics. For this reason cannabis is traditionally smoked, providing the most predictable and titratable route for administration. For therapeutic development pulmonary deliveries of cannabinoid aerosols are under investigation as an alternative. 

Gastrointestinal absorption of aluminum is low, generally in the range of 0.1-1 % in humans as discussed in Section 2.3.1.2. Absorption of aluminum compounds is largely determined by its bioavailability in the aqueous conditions of the gut, which is mainly related to pH, the presence of complexing ligands with... 

Gastrointestinal absorption Unchanged passive diffusion and no change in bioavailability for most drugs 1 Active transport and bioavailability for some drugs 1 First-pass effect and bioavailability... 

Fig. 2 Summary of processes involved following the oral administration of a drug in tablet or capsule form. (From Blanchard, J. Gastrointestinal absorption. II. Formulation factors affecting bioavailability. Am. J. Pharm. 1978, 150, 132-151.)...

B. Timmermann/U. of Arizona Curcuma longa rhizome (turmeric), Zingiber Officinale Rhizome (ginger), Boswellia serrata (boswellin) Determine the active components and their ability to regulate inflammation Characterize the disposition, gastrointestinal absorption kinetics, and bioavailability Assess the pharmacokinetic and pharmacodynamic characteristics In vitro Animals Phase I trial... 

McLachlan et al. 1991b Meiri et al. 1993 Yokel 2000). Recent investigations suggest that AD is associated with enhanced bioavailability of certain aluminum species. AD patients have greater gastrointestinal absorption than controls, and specific exposure to organic monomeric aluminum increases risk of AD compared with exposure to other forms of aluminum (Gauthier et al. 2000 Moore et al. 2000). 

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