Bioavailability assay

The two patents described above were particularly important in the initiation of the developments of biodesulfurization catalysts. The bioreactor arrays required for operation and growth method constituted key elements in the following developments of the area, which would condition viability and successful path to industrialization. A sulfur bioavailability assay was incorporated into the screen for monitoring the sulfur uptake by the microorganisms, and the concept formed a claim in the patents [67,91], The objective... 

Fig. 2. A diagram illustrating the presentation and interpretation of data obtained from a bioavailability assay developed by Guerin and Boyd (1992). 

A very important advantage of the relative bioavailability assay is that experimental parameters may be selected which are easily quantitated. Thus, Tso et al. (11) determined the relationship between dietary calcium concentration (X, g/kg) and... 

The following criteria for a good bioavailability assay are appropriate, (a) It must be dose responsive. For an... 

Geebelen, W., Adriano, D., and van der, L. D. (2003). Selected bioavailability assays to test the efficacy of amendment-induced immobilization of lead in soils. Plant Soil 249, 217-228. 

Compound solubility is important because it affects the bioavailability of compounds in vivo, the behavior of compounds in in vitro assays, and the ease with which preclinical in vivo studies can be run. Solubility assays that measure either... 

The last step of the drug discovery process involves the testing of lead compounds to address issues such as efficacy, bioavailability, and safety. Testing may include in vitro assays but ultimately would require a suitable disease model and studies in animals. Many compounds may need to be designed and synthesized to identify the one compound with all the desired properties. Such a compound can be advanced to preclinical studies and eventually to the clinic. 

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