Bioartificial materials polymerization

However, the main goal was to study the behavior and performance of a novel bioartificial material (obtained with an innovative method involving prefreezing and inversion steps) as a suitable matrix for the entrapment of proteins or enzymes in a stable manner. The tests performed (determination of enzyme activity, determination of and V ax kinetic parameters, repeatability test) confirmed both that the enzyme immobilised in the bioartificial polymeric matrix maintained its catalytic activity unchanged and that the catalytic reaction rate was comparable with that of the free a-amylase reaction (used as control). 

Albertsson and Srivastava (53) produced copolyesters from l,5-dioxepan-2-one and e-caprolactone via lipase catalysis the resulting material was porous and potentially suited for tissue engineering. As noted earlier, Silvestri, et al (7) developed bioartificial polymeric materials with the aim of producing... 

III. Enzyme-based Bioartificial Polymeric Materials through Template Polymerisation ... 

The authors are sincerely grateful to all the people that worked in the last decade on Bioartificial Polymeric Materials with Enzymatically Controlled Functional Properties. 

D Urso, E.M. and G. Fortier, New bioartificial polymeric material poly(ethylene glycol) cross-linked with albumin. I. Synthesis and swelling properties,/curna( of Bioacth e and Compatible Polymers, 9 (1994) 367-387. 

Polymeric materials are extensively utilized in the biomedical field. While it is much easier to employ synthetic polymers in the biomedical field, natural polymers are also essential owing to their biocompatibility and biodegradability. An additional method of fabrication of polymeric materials for biomedical applications is to mix together synthetic polymers with natural ones. Growing interest in innovative materials based on blends of two or more polymers has been studied through the last three decades. Blends of synthetic and natural polymers can shape a novel class of materials with superior mechanical properties and biocompatibility in comparison those of single components. This emerging class called as bioartificial or biosynthetic polymeric materials [15-18]. Natural polymers are typically biocompatible, while synthetic polymers can include a residue of... 

Giusti P, Lazzeri L, LeUi L. Bioartificial polymeric materials a new method to design biomaterials by using both biological and synthetic polymers. TRIP. 1993 1 261-7. 

Giusti P, Lazzeri L, Petris S, PaUa M, Cascone MG. Collagen based new bioartificial polymeric materials. Biomaterials. 1994 15 1229-33. 

Cascone MG. Dynamic-mechanical properties of bioartificial polymeric materials. Polym Int. 1997 43 55-69. 

C. CristalHni, N. Barbani, P. Giusti, L. Lazzeri, M. G. Cascone, and G. CiardelH, Polymerisation onto biological templates, a new way to obtain bioartificial polymeric materials. Macromol. Chem. Phys. 202, 2104-2113 (2001). 

Giusti, R, L. Lazzeri, and L. Lelli (1993). Bioartificial polymeric materials, TRIP, 1,352. 

Cascone, M.G., Giusti, P., Lazzeri, L., Pollicino, A., and Recca, A. (1996) Surface characterization of collagen-based bioartificial polymeric materials. J. Biomater Sci. Polym. Ed., 7, 917-924. 

A variety of systems can be employed for cell or enzyme immobilization. These include, for example, microcarriers, gel entrapment," hoUow fibers, encapsulation and conformal coatings. The latter three have been extensively tested in small animal models over the last 20 years, particularly in the area of diabetes therapy. The polymeric materials used in bioartificial endocrine devices (the terms bioartificial and endocrine device are often distinguished from artificial organs due to the presence of tissue in the former two) serve two major purposes ... 

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