Bioactive stilbenes

McKenzie, J.L., R.M. Ikeda, T.R. Terrill, D.G. Vickroy, and D.B. Walters (editors) Recent advances in the chemical composition of tobacco and tobacco smoke, Proc. Am. Chem. Soc. Symp., New Orleans, LA (1977). Medina-Bolivar, P, C. Nopo-Olazabal, L. Nopo-Olazabal, G. Sivakumar, and 1. Condori Screening for bioactive stilbenes in the genus Nicotiana, Recent Adv. Tob. Sci. 33 (2007) 93-100. 

Combretastatins, a series of bioactive stilbenes (combretastatin A series), bibenzyls (B series), phenanthrenes (C series), and macrocycUc lactone (D series), were obtained from the African wiUow tree Combretum caffrum (Combretaceae). Among them, the A series of combretastatins belonging to stilbenes, including combretastatins A-1 to A-6 2—7, are found to be tubulin polymerization inhibitors. 

In contrast, a number of alkene epoxides (10.3) are chemically quite stable, i.e., intrinsically less reactive than arene oxides. Examples of epoxide metabolites that have proven to be stable enough to be isolated in the absence of degrading enzymes include 1,2-epoxyoctane (10.4), 1,2-epoxycyclohex-ane (10.5), 1-phenyl-1,2-epoxy ethane (styrene oxide, 10.6), and cis- 1,2-diphenyl-1,2-epoxyethane (cfv-stilbene oxide, 10.7) [12], The same is true of alclofenac epoxide (10.8), hexobarbital epoxide (10.9), and a few other epoxides of bioactive compounds. 

Stilbenes are the most heavily investigated small molecules for bioactivities of all the stilbenoids, especially resveratrol (1) and its analogs. In this review, stilbenes are classified into five groups ... 

The prenylflavanones with either prenyl-, lavandulyl-, or geranyl groups on the A ring, two bioactive flavonostilbenes on the ringB, and stilbene... 

Bioactivity-guided fractionation of the methanolic extract of Caragana chamlague (Leguminosae) resulted in the isolation of two active stilbene oligomers, (+)- -viniferin (635) and kobophenol A as... 

Bibenzyls bioactivities biosynthesis bisbibenzyls occurrence oUgostilbenes phenanthrenes phytochemistry stilbenes stilbenoids... 

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