Bioactive monoterpenoids

Chiral monoterpenoids in plants-enantioselective chromatographic analysis, and their bioactivity... 

CHIRAL MONOTERPENOIDS IN PLANTS -ENANTIOSELECTIVE CHROMATOGRAPHIC ANALYSIS, AND THEIR BIOACTIVITY... 

In this article the gas-chromatographic methods adequate for an analysis of chiral monoterpenoids are presented. Recent results on the enantiomeric composition of monoterpenoids from different species of plants are discussed. The bioactivity of selected chiral monoterpenoids is also described. 

There are, however, a few examples in which the exclusive participation of peroxidase in the synthesis of natural bioactive alkaloids has been reported. These mainly concern the biosynthesis of some monoterpenoid indole alkaloids, especially the synthesis of a-3 ,4 -anhydrovinblastine (XLVII) [76],... 

U. tomentosa is a significant traditional medicinal plant that is an important source of monoterpenoid oxindole alkaloids (MOAs) with bioactivities including immunomodulatory, cytotoxic, anti-HIV, and antileukemic activities [100]. It will be of interest to understand biosynthetic insights of bioactive compounds of this plant as an example here. Studies have reported the regulation of biosynthesis of sterols and triterpenes in U. tomentosa [100]. Administration of pectin to U. tomentosa cell suspension cultures increased the activity of isopentyl diphosphate isomerase of ursolic and oleanolic acid. The treated cells also transformed a higher percentage of labeled mevalonic acid precursors into triterpenes and resulted in the decrease in activity of far-nesyl diphosphatase by a factor of two when compared to the control. The... 

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