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Binding site stability

The oxyanion binding site stabilizes the transition state by forming two hydrogen bonds to a negatively charged oxygen atom of the substrate. Mutations that prevent formation of one of these bonds in subtilisin decrease the rate by a factor of about 10. ... [Pg.219]

Motomura, T. and Aoyama, Y. (1992) Accumulation of hydrogen-bonding and electrostatic binding sites stabilization of salts in hydroxylic media via intramolecular hydrogen bonding, J. Org. Chem. 57, in press. [Pg.28]

In the case of L-type Ca2+ channels, they also carry binding sites for Ca2+ antagonist drugs. The accessory a2-5, p, and y subunits stabilize Ca2+ channel function and support its targeting to the plasma membrane. Notably other proteins can associate with the channel complex allowing the formation of signaling complex important for channel targeting and modulation. [Pg.296]

In contrast, jasplakinolide, a cyclodepsipeptide from the marine sponge Jaspis johnstoni, rapidly penetrates the cell membrane. It competes with phalloidin for F-actin binding and has a dissociation constant of approximately 15 nM. It induces actin polymerization and stabilizes pre-existing actin filaments. Dolastatin 11, a depsipeptide from the mollusk Dolabella auricu-laria, induces F-actin polymerization. Its binding site differs from that of phalloidin or jasplakinolide. [Pg.417]

Tetracycline has a secondary binding site in the H27 switch region that may also be fimctionally significant. The dtug binds at the interface of the three domains of 16S rRNA, close to helix 44 and between helices 11 and 27. As with the primary binding site, contacts are made from the hydrophilic face of the dtug to the backbone of 16S rRNA. In this binding site, tetracycline may function to stabilize the ram state. [Pg.1087]


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See also in sourсe #XX -- [ Pg.35 , Pg.36 ]




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