Binding of oxygen

The Physiological Significance of Cooperative Binding of Oxygen by Hemoglobin... 

Another stndy on binding to NHC complexes, that combined experiments and DFT (density functional theory) calculations was recently reported on a ruthenium system. This study shows the reversible binding of oxygen to the tetra-NHC complex [Ru(NHC) H)][BAr/] 6 (BAr/ = B (3,5-CF3) C H3 ), which leads to complex 7 (Scheme 10.2) [12]. Unexpectedly, the chemical shift of the hydride ligand undergoes a large downfield shift upon coordination to (from -41.2 ppm... 

In some of his earliest work, published in 1910, A. V. Hill examined how the binding of oxygen to hemoglobin varied with the oxygen partial pressure. He found that the relationship between the two could be fitted by the following equation ... 

In a recent paper a detailed mechanistic study of this reaction was presented (108). The first step is the reversible binding of oxygen by forming a u-peroxo species. This intermediate reacts further via an irreversible step to the hydroxylated product. The kinetic measurements at high pressure were performed at -20°C, since at room temperature no peroxo intermediate can be observed. The forward reaction of the Cu(I) complex with oxygen is characterized by a strongly... 

In the next section we describe some experimental data on the binding of oxygen to Hb. We shall focus on the efficiency of the loading and unloading of oxygen at two not-too-different partial pressures. 

One of the most important functions of blood is the binding of oxygen by haemoglobin and its transport to the tissues. Administration of blood and blood products, however, carries with it a number of risks (Table 20.3) and are not always the initial choice to replace blood or plasma loss. Blood and blood products are also expensive, have a limited availability, and a very limited shelf life. A number of alternative oxygen-carrying fluids have been developed, and some are close to release for clinical use. 

---