Warfarin Bicalutamide

BICALUTAMIDE ANTICOAGULANTS-WARFARIN t plasma concentrations of warfarin Bicalutamide displaces warfarin from protein-binding sites Monitor INR at least weekly until stable at initiation and discontinuation of concurrent therapy... 

The manufacturer has on record a few cases of flutamide possibly increasing the anticoagulant effects of warfarin. In vitro, bicalutamide displaced warfarin from its protein binding sites. The clinical relevance of this, if any, has not been assessed. In vitro, nilutamide inhibited P450 isoenzymes, and might therefore interact with coumarins, although there does not appear to be any further information on this. 

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