Beta-adrenergic agonists dosing

Metaproterenol (Alupent, Metaprel) [Bronchodilator/Beta Adrenergic Agonist] Uses Asthma rev ible bronchospasm Action Sympathomimetic bronchodilator Dose AduUs. Inhal 1-3 inhal q3-4h, 12 inhal max/24 h wait 2 min between inhal PO 20 mg q6-8h Peds. Inhal 0.5 mg/kg/dose, 15 mg/dose max inhaled q4-6h by neb or 1-2 puffs q4-6h PO 0.3-0.5 mg/kg/dose... 

Metaproterenol (Alupent, Metaprel) [Bronchodilator/ Beta-Adrenergic Agonist] Uses Asthma reversible bronchospasm Action Sympathomimetic bronchodilator Dose Adults. Neb 0.2-0.3 mL in 2.5-3.0 mL of NS Peds. Neb 0.1-0.2 mL/kg of a 5% soln in 2.5 mL NS Caution [C, /-] Contra Tach, other arrhythmias Disp Aerosol 0.65 mg/inhal soln for inhal 0.4, 0.6% tabs 10, 20 mg syrup 10 mg/5 mL SE Nervousness, tremors (common), tach, HTN Interactions T Effects W/ sympathomimetic drugs, xanthines T risk of arrhythmias W/ cardiac glycosides, halothane, levodopa, theophylline, thyroid hormones T HTN W/ MAOIs effects W/ BBs EMS Separate additional aerosol use by 5 min fewer 3i effects than isoproterenol longer-acting monitor lung sounds before/after administration... 

Clonidine (Catapres) is an alpha-2 adrenergic agonist, which thereby functions as a presynaptic irdiibitor of norepinephrine release. It is usually used to treat hypertension (like the beta blockers) but has been used to treat amciety disorders with some success. It is also used to treat opiate withdrawal. A typical starting dose is 0.1 mg two to three times daily (see figure 16-C). It is also available as a transdermal patch. 

Tobacco smoke reduces serum levels of a wide range of drugs and dose adjustment may be necessary when smokers have given up, particularly with theophylline, beta-blockers, adrenergic agonists, nifedipine, tricyclic antidepressants, phenothiazines, benzodiazepines and insulin. 

Dobutamine is a betaj, beta2 and alphaj adrenergic agonist and carvedilol is a non-selective beta blocker, but at low doses it is primarily a selective betaj adrenergic antagonist and it is also an alphaj antagonist. It was proposed that the drop in blood pressure was caused by vasodilation due to vascular beta2 receptor activation, which was not blocked by low doses of carvedilol. ... 

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