Berson, Solomon

Separation of Purines Berson, Solomon A., sec Yalow, Rosalyn S. Bhatti, Tarig see Clamp, John R. 6 79... 

Immunoassay as an analytical technique was introduced by Rosalind Yalow and Solomon Berson in 1960 with their use of anti-insulin antibodies to measure the concentration of the hormone in plasma. This advance, for which Rosalind Yalow was awarded the Nobel prize, was probably the most important single advance in biological measurement of the following two decades. Examples of the use of immunoassay may now be found in almost all areas of analytical biochemistry. 

For their work on hypothalamic hormones, Schally and Guillemin shared the Nobel Prize in Physiology or Medicine in 1977, along with Rosalyn Yalow, who (with Solomon A. Berson) developed the extraordinarily sensitive radioimmunoassay (RIA) for peptide hormones and used it to study hormone action. RIA revolutionized hormone research by making possible the rapid, quantitative, and specific measurement of hormones in minute amounts. 

Rosalyn Yalow received the Nobel Prize in medicine in 1977 for developing immunoassay techniques in the 1950s, using proteins labeled with radioactive, 3,l to enable their detection.13 Yalow. a physicist, worked with Solomon Berson, a medical doctor, in this pioneering effort. 

Rosalyn Sussman Yalow (bom 1921) and Solomon Aaron Berson (1918-1972) developed the... 

The first immunoassay technique was the isotopic dilution radioimmunoassay, developed by Rosalyn Yalow and Solomon Berson for the detection of insulin in human blood. This work gained Yalow a share of the 1977 Nobel Prize for Physiology and Medicine, but Berson was not honored because of Nobel rules stating that the prize cannot be awarded posthumously. The following passage, translated from the presentation speech, explains the technique in simple terms ...As a result of mixing in a test tube a known quantity of radioactive insulin with a known quantity of antibodies against insulin, a... 

Rosalyn Yalow, coinventor with Solomon Berson of the sensitive radioimmunoassay analytical procedure used in medicine and biology, passed away during the writing of this book. In 1977, she became only the second woman to receive the Nobel Prize for Physiology or Medicine. Berson should have shared that prize, but he died in 1972 and the prize is not awarded posthumously. Radioimmunoassay is an example of a tremendously important contribution to chemical analysis made by someone other than an analytical chemist. ... 

In the 1950s Solomon Berson, chief of the radioisotope service in the Bronx Veterans Administration Hospital in New York, and his collaborator, Rosalyn Yalow, made a detailed study of the binding of insulin to an anti-insulin antibody they found in the plasma of patients who had received injections of bovine insulin for... 

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