Benzylphosphine oxide

Mesyats, S.R, Tsvetkov, E.N., Petrov, E.S., Shelganova, N.N., Shcherbina, T.M., Shatenshtein, A.L, and Kabachnik, M.L, Equilibria CH acidity of phosphorus-containing organic compounds. Part 2. Substituted benzylphosphine oxides and several of their analogs, Ev. Akad. Nauk SSSR, Ser. Khim., 2497, 1974 Bull. Acad. Sci. USSR, Div. Chem. Sci. (Engl. Transl.), 2406, 1974. 

A series of C3-symmetric triprolinamides based on triphenyl- and tri-benzylphosphine oxides were synthesized that were used as catalysts in asymmetric aldol reactions (Scheme 33). ... 

Phosphine oxides are among various functionalities that can be introduced into aromatic alkynes via a Pd-catalyzed benzannulation reaction. Thus, the reaction between readily available enynes 70 with 5,7-dodecadiyne resulted in the formation of the corresponding benzylphosphine oxide 71 in good yields [20] (Scheme 14.28). 

SCHEME 14.28 Synthesis of benzylphosphine oxides Pd-catalyzed [4 + 2] cross-benzannulation of enynes with diynes. 

The Keglevich group has continued to deal with environmentally friendly and P-heterocyclic chemistry. The solid liquid phase alkylation of P=0-functionalised CH acidic compounds was accomplished under phase transfer catalytic and microwave (MW) conditions." a-Hydroxy-benzylphosphine oxides were synthesized by the addition of diphenylphosphine oxide to the carbonyl group of substituted benzaldehydes under MW conditions." The double Kabachnik-Fields (phospha-Mannich) reaction was utilized in the preparation of bis(phosphinoxidomethyl)amines. The Diels Alder cycloadditions of 1,2-dihydrophosphinine oxides and subsequent... 

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