4 -Benzyloxy-2 2 ethylamino propiophenone

A solution of 44 grams of 2-bromo-4 -benzyloxypropiophenone and 44 grams of 2-(4-meth-oxyphenyDethylamine in 270 ml of ethanol was refluxed for 3 hours. Then the ethanol was distilled off in vacuo and the concentrate mixed with ether. The resulting crystallizate was Sucked off after which the filtrate was mixed with an excess of 2 N hydrochloric acid. As a result of this the hydrochloride of 4 -benzyloxy-2-[2-(4-methoxyphenyl)ethylamino]-propiophenone slowly crystallized. This substance was also Sucked off, washed with water and alcohol, and dried in vacuo. After recrystallization from dilute alcohol the yield was 25.5 grams of a product with a melting point of 217 to 218°C. 

Eqn. (a) shows the reaction between 2-bromo-4 -benzylox3rpropiophenone and 2-(4-methoxyphenyl)-ethylamine in the presence of ethanol to 3neld an intermediate 4 -benzyloxy-2[2[4-methoxy-phenyl) ethylamino] propiophenone (I). 

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