3-benzyl-5.5-dioxo-9-

Purine, 1,6-dihydro-8,9-dimethyl-6-thioxo-synthesis, 5, 583 Purine, 2,6-dimethoxy-synthesis, 5, 596 Purine, 2,6-dimethoxy-7-methyl-rearrangement, 5, 558 Purine, 2,7-dimethyl-halogenation, 5, 547 Purine, 7,9-dimethyl-UV spectra, 5, 517 Purine, 8,8-dimethyl-synthesis, 5, 580 Purine, 6-dimethylamino-mass spectra, 5, 519 occurrence, 5, 600 Purine, 6-dimethylamino-9-benzyl-alkylation, 5, 531 Purine, 3,7-dimethyl-6,8-dioxo-methylation, 5, 534 Purine, 6,8-dioxo-alkylation, 5, 534... 

N-PHTHALYL-l-P-PHENYLALANINE (2-Isoindolineacetic acid, [Pg.82]

It was observed already by BougaulU that the reaction of 6-benzyl-3,5-dioxo-2,3,4,5-tetrahydro-l,2,4-triazines with alkyl halides in an alkaline solution yields a mixture of the 4-mono- and 2,4-dialkyl derivatives. This mixture of alkylation products can be readily sepa-... 

The preparation of W-alkyl derivatives of 6-benzyl-3,5-dioxo-l,2,4-triazine by hydrolysis of the corresponding alkylmercapto derivatives was systematically studied by Cattelain. The conversion to known alkyl derivatives of dioxotriazines was used to determine the structure of alkylated methylmercapto derivatives. As will be shown later (e.g., Section H,B,4,b) this procedure has a general preparative significance for 1-alkyl derivatives of 6-azauracil. ... 

Other oxo-j8-carbolines which have been converted into 1,2,3,4-tetrahydro-j8-carbolines are 2-benzyl-1,2,3,4-tetrahydro-1,3-dioxo-j8-carboline (85 R = CH2C6H5), which was reduced to 2-benzyl-1,2,3,4-... 

Benzyl-l,3-dioxo-l,2,3,4-tetrahydro-j8-carboline (189) was prepared by heating the benzylamide 188 with polyphosphoric acid on a... 

Chemical Name (+)-1 -Benzyl-4-[(2,6-dioxo-3-phenyl)-3-piperidyl] piperidine Common Name Dexbenzetimide dextrobenzetimide benzetimide Structural Formula ... 

CnHi O, 620-79-1) see Diazepam Nimetazepam ethyl (la,5a,6a)-3-benzyl-2,4-dioxo-3-azablcyclo[3.1.0] hexane-6-carboxylate... 

Synthesis of 2,3-disubstituted 7-fer/-butylpyrazolo[l,5-3][l,2,4]triazincs were reported by McNab and co-workers <2003OBC4268>. The reaction (Scheme 45) followed an earlier pathway the 1,5-diaminopyrazole derivative 303 was reacted with a dioxo reagent (diacetyl or benzyl) to yield the ring-closed product 304 in poor to medium yield (27-54%). 

Substrates include benzyl (2 g) and cinnamyl (2.7 g) alcohols to acids cyclopentanol (1 g), benzhydrol (3.9 g), benzoin (4 g), pantolactone (2.6 g) to ketones (RuCy TCCA/( Bu N)Br/aq. Kj(C03)/CH3CN) (Fig. 2.14) [25] [[2-[2-hydroxypropyl) amino]-l,2-dioxoethyl]amino]acetic acid ethyl ester (6.21 kg) to [(l,2-dioxo-2-oxopropyl)amino]ethyl)amino] acetic acid ethyl ester, part of the industrial-scale synthesis of thrombin inhibitor (RuCyaq. Na(BrOj)/CH3CN) [166] (H-)-dihydroc-holesterol (8 g) to cholest-3-one (RuO /aq. K(10 )/(BTEAC)/CHCl3) [308] ... 

Methylene groups adjacent to the N atom in tertiary polycyclic amines were oxidised by RuO /aq. Na(IO )/CCl, depending on reaction conditions. Thus A -benzyl-9-azabicyclo-[l, 3, 3]-nonane yielded AT-benzoyl-9-azabicyclo-[l, 3, 3]-nonane (Fig. 5.5) and A -benzyl-l,3-dioxo-iso-quinoline gave the A -benzoyl compound, while A -benzyl-5,6-dihydro-llH-dibenz[b,e]azepine, which has exi and endocydic benzyl groups, were oxidised to the N-benzyl-6-oxo derivative [41]. 

The potassium salt of 7-methyl-3-phenyl-2,4-dioxo-l,2,3,4-tetrahydropyrido[2,3- pyrimidine-5-carboxylate 153 was condensed with l-bromo-3-chloropropane or 1,4-dibromobutane in anhydrous DMF at room temperature to afford the A-l-alkyl derivatives 154 and 155, respectively <1994FA499>. The corresponding A-l-piperazinylalkyl derivatives of 153 were also prepared in more than 40% yield. Debenzylation of 6-benzyl-3-methylpyrido[4,3-,7 pyrimidine 156 by Pd/C-catalyzed hydrogenolysis in AcOH gave the analogue 157 <1994JHC1569>. 

III l-Benzyl-3 ethyl-2,4-dioxo-l,2,3,4-tetrahydro-(1,3,5-iriazino I 2-a benzimidazol> 94% Schmp. 191-192°... 

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