2-Benzyl-5,8-dimethoxy-1,2,3,4-tetrahydro

Brommethyl-benzyl)- bzw. 5,6-Dimethoxy-2-(3,4-dimethoxy-2-brommethyl-bcnzyl)-isochinolinium-bromid wird in DMF unter Dehydrohalogenierung zu 5,6,11,12-Tetrahydro-5-aza-l,2-benzanthracen bzw. Xylopinin cyclisiert1 ... 

HlS,3,S,)-2-Benzyl-l,2,3,4-tetrahydro-7-(2-hydroxymethyl-4,5-dimethoxy-l-naphthalenyl)-6-methoxy-l,3-dimethyl-8-isoquinolinol (7)1 12 ... 

Analog erhalt man Brom- und Alkoxycarbonyl-substituierte Produkte wie z.B. 1-( 2-Brom-4-methoxycarbonyl-benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isochinolin (61%). Ein Beispiel aus der Steroid-Chemie ist die Herstellung von / 7fi-Dimelhylamino-3-hydroxy-17a-methyl-5-androsten aus einem Iminium-Salz2 ... 

Die Stevens-Umlagerung von 2-Benzyl-7,8-dimethoxy-2-methyl-l,2,3,4-tetrahydro-isochinolinium-bromid mittels Phenyl-lithium ergibt l-Benzyl-7,8-dimethoxy-2-methyl-l, 2,3,4-tetrahydro-isochinolinz ... 

HacoXX N CH3r ch3 J0 NaTeH/Q[Ha -OH Ruckfl. 6,7-Dimethoxy-l-( 3,4-dimethoxy-benzyl-1,2,3,4-tetrahydro-isochinolin 87 3... 

Isoquinoline, 2-acetyl-l,2,3,4-tetrahydro-6,7-dimethoxy-1-methylene-, 56, 4 Isoquinohne, 2 benzoyl 1-benzyl 1 cyano 1,2-drhydro-, 56, 23 Isoquinohne, 2-benzoyl-l-cyano-l, 2-di-hydro-, 56, 20... 

Bromotrimethylsilane has proven to be useful for a wide variety of applications most of them being reviewed.5 8 Other recent applications are mild cleavage of oxiranes,9 the synthesis of glycosyl bromides,10 the selective cleavage of tetrahydro-2,5-dimethoxyfuran and tetrahydro-2,6-dimethoxy-pyran,11 the cleavage of esters and ethers,12 and the synthesis of benzyl bromides.13... 

Dimethoxy -2-methyl-1 -(3,4 -dimethoxy -benzyl)-1,2,3,4 -tetrahydro-isochinolin 2... 

Alkyl-4,5,6,7-tetrahydro- 311 5-Amino-2-benzyl- 536 5-Amino-4,7-dimethoxy- 536 4-Aminomethyl- 311 4-Aminomethyl-4,5,6,7-tetrahydro- 311... 

Alkyl-l-(3,4-dimethoxy-phenyl)- -jodid 5-Brom-8-nitro 2-alkyl- 276 7-ChIor-4-hydroxy-2-benzyl- -chlorid 276f. 2,2-Dimethyl-1,2,3,4-tetrahydro- -jodid 675 5-Hydroxy- 2-athyl- -bromid 275 f. 2-[2-lndolyl-(3)-athyl]-4,5-dimethoxycarbonyl--bromid 280 5-Nitro-2-alkyl- 276... 

Evidence of the sp/ro-indolenine mechanism also comes from the cyclization of certain a-aryl tryptamines with aromatic aldehydes. In the case of aryl substiments that are particularly electrrMi-rich (3,4-dimethoxy 3,4-methylenedioxy), isomeric tetrahydro-y-carbolines resulting from the competing migration of the electron-rich benzyl group predominate in a ratio of about 4 1 [319]. 

A soln. of rac-2-benzyl-6,7-dimethoxy-4-(4-methoxyphenyl)-l,2,3,4-tetrahydro-4-isoquinolinol hydrodiloride in ethanolic 35%-HCl refluxed 2 hrs., the crude inter-... 

Dimethoxy 2-methyl-l. [S.4-methyIen dioxy- .oyan-benzyl]-l.2.3.4-tetrahydro-isochinolin 27 II 590. 

Dimethoxy 1 -nitroiuethyl-2-[2.3>(Umetli OJ5r-benzyl]-1.2.3.4-tetrahydro.isochlnolin 81 Hill. 

C22H30INO2, 2-Benzyl-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isopropyl-isoquinolinium iodide, 45B, 284 C23H,7N02r 1-Isoquinolyl(phenyl)methyl benzoate, 45B, 285 C2 3H2 oBr2N2O5, Dimethyl 1,2-bis-(4-bromophenyl)-3,5-dimethyl-4-oxo-6,7-diazabicyclo[3.2.0]hept-2-ene-6,7-dicarboxylate, 38B, 297 C2 3H21N3O5, 4-Ethoxycarbonyl-5-methoxy-1-phenyl-3-(a-phthalimidoeth-yDpyrazole, 46B, 265... 

C2 5H2 3N5O5, 2-Acetamido-8-methyl-4,9-dioxo-6,7-diphenyl-6,7,8,9-tet-rahydro-4H-pyrazino[1,2-a]-s-triazine dihydrate, 41B, 336 C2 5H2 8INO2 f 2-Benzyl-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1 -phenylisoquinolinium iodide, 43B, 350 C26H19N3, 1,3,5-Triphenyl-1H-1,2,4-benzotriazepine, 44B, 246 C26H2oBr2Nfi, 1,1 -Azo-2-phenylimidazo[1,2-a]pyridinium dibromide, 38B, 86... 

Cupric oxide added at 130° to a mixture of l-(3-benzyloxy-2-bromo-4-methoxy-benzyl)-5-bromo-l,2,3,4-tetrahydro-8-hydroxy-7-methoxy-2-methylisoquinoIine, K-carbonate, and pyridine, then refluxed 4 hrs. at 160° -> 8-benzyloxy-4-bromo-2,3,12,12a-tetrahydro-6,9-dimethoxy-l-methyl-lH-[l]benzoxepino[2,3,4-ij]isoquino-line. Y 87.5%. Also with Cu-powder and f. e. s. T. Kametani, K. Fukumoto, and M. Fujihara, Chem. Pharm. Bull. 20, 1800 (1972). 

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