2.4.5- Trimethoxy benzoic acid

By oxidation asarone yields asarylic aldehyde, CgH2(CHO)(OCH3)g, melting at 114°, and finally asarylic acid, CgH2(COOH)(OCH3)3, melting at 144°. This acid is, of course, identical with trimethoxy-benzoic acid. 

Figure 12.12 THM GC/MS curves of a Winsor Newton lemon alkyd paint (a) and of an alkyd sample taken from Fontana s work Concetto spaziale (1961) (b). Peak assignments 1, 1,3 dimethoxy 2 propanol 2, 1,2,3 trimethoxy propane 3, 3 methoxy 1,2 propandiol 4, 4 chloro benzenamine 5, 3 methoxy 2,2 bis(methoxymethyl) 1 propanol 6, 3 chloro N methyl benzenamine 7, 3 methoxy 2 methoxymethyl 1 propanol 8, 4 chloro N methyl benzenamine 9, phthalic anhydride 10, 3 chloro 4 methoxy benzenamine 11, suberic acid dimethyl ester 12, dimethyl phthalate 13, azelaic acid dimethyl ester 14, sebacic acid dimethyl ester 15, palmitic acid methyl ester 16, oleic acid methyl ester 17, stearic acid methyl ester 18, 12 hydroxy stearic acid methyl ester 19, 12 methoxy stearic acid methyl ester 20, styrene 21, 2 (2 methoxyethoxy) ethanol 22, 1,1 oxybis(2 methoxy ethane) 23, benzoic acid methyl ester 24, adipic acid dimethyl ester 25, hexadecenoic acid methyl ester 26, dihydroisopimaric acid methyl ester 27, dehydroabietic acid methyl ester 28, 4 epidehydroabietol...

HI BENZOIC ACID. 3,4,5-TRIMETHOXY-, 2-(4-(3-(2-CHLOROPHENOTHIAZIN-lO-YL JPROPYL)-1-PIPERAZINYL) ETHYL ESTER... 

Reserpine is metabolised by the liver (3 2-3U) with more than 90% excreted as metabolites(33). The major urinary metabolites are methyl reserpate and 3,5-trimethoxy-benzoic acid. Other metabolites are shown in Scheme 3 (35). 

The enzymic oxidative deamination of simple phenethylamines is exemplified by the reported bio transformations of mescaline (146) (114, 115) and ephedrine (148) (116). Mescaline is metabolized to 3,4,5-trimethoxy-phenylacetic acid by tissue homogenates of mouse brain, liver, kidney, and heart (114,115). 3,4,5-Trimethoxybenzoic acid is also formed as a minor metabolite. The formation of jV-acetylmescaline (147), a significant metabolite in vivo, was not observed in the in vitro studies. Both D-(—)-and L-(+)-ephedrine have been incubated with enzyme preparations from rabbit liver norephedrine (149), benzoic acid, and 1-phenyl-1,2-propanediol were characterized as metabolites (116). The D-(—)-isomer was the better substrate, being more rapidly converted. Similar results were previously reported with rabbit liver slices as the source of enzyme (153,154). The enzymic degradation of the side chain of /i-phenethylamines has been extensively investigated with nonalkaloid substrates such as amphetamine (151) and jV-methylamphetamine (150) (10,155-157), and the reader is referred to these studies for a more comprehensive coverage of this aspect of the subject. 

SYNS FRENOLON DIFUMARATE METHOPHEN-AZATE ACID FUMARATE PHRENOLAN T-82 DIFUMARATE 3,4,5-TRIMETHOXY-BENZOIC ACID 2-(4-(3-(2-CHLOROPHENOTHLAZIN-10-YL)PROPYL)-1-PIPERAZINYL)ETHYL ESTER, DIFUMARATE... 

Example 3-Diethylamino propyl ester of 3,4,5-trimethoxy benzoic acid. 

CYP53 Benzoic acid (and derivatives) hydroxylation and trimethoxy-trans-stilbene 0-demethylation Benzoate and its derivatives degrada-tion/detoxification and synthesis of stilbene derivatives A. niger,A. nidulans, Cochliobolus luna-tus, P. chrysosporium and Postia placenta [502, 827 830]... 

---