3.4- Diamino benzoic acid

Hippuric acid is a normal product of metabolism. It is produced in the kidney by the enzymic union of benzoic acid and glycine (Schmiede-berg and Bunge, 1877). In birds benzoic acid is rendered innocuous by combination with ornithine (aS-diamino-valeric acid) to form the dibenzoyl-derivative, so-called ornithuric acid (Jaffe). 

Ornithine or a, h-diamimrvalerianic Acid.—In 1877 JafTe obtained from the urine of birds, which he had fed with benzoic acid, dibenzoyl ornithine or ornithuric acid, and from this substance he prepared ornithine chloride. He regarded it as a diaminovalerianic acid, the first known representative of the series of diamino acids, but only in 1898 was the position of the two amino groups definitely determined by Ellinger, who obtained putrescine from it by putrefaction the identity of putrescine with tetramethylenediamine had been previously shown by... 

It is diamino diphenyl sulfone (DDS), chemically related to sulfonamides, have been used effectively in the long term treatment of leprosy. Its mechanism of action is same as that of sulfonamides i.e. inhibition of paraamino benzoic acid... 

Like acetonitrile, benzonitrile is a powerful solvent fnr many inorganic and organic materials including some polymers. It can be converted to a large number and variety of derivatives by simple syntheses e.g.. by hydrolysis, it can be converted to either benzoic acid nr benzamicle. The most important reaction is with dicyandiamide to produce 2,4-diamino-6-phenyl-l,3,5-triazine (benzogunnamine) ... 

In one case, methyl terephthalic acid, obtained in two steps from p-formyl-benzoic acid, was converted to the phenacyl bromide (340) in the usual manner. Alkylation of 2,5-diamino-4,6-dihydroxypyrimidine with (340) with subsequent cyclization produced the dihydrooxazine pteroate ester (341), which was hydrolyzed to (342) [173]. Coupling (342) with diethyl L-glutamate using isobutyl chloroformate [ 174] yielded the diester (343a) which was then saponified to the dihydrooxazine FA analogue without the C-9,N-10 bridge (343b). 

Amino-6-nitro-Fischer s base (36, R = N02) was reduced to the 5,6-diamino compound (36, R = NH2) in 80% yield, which (as its hexachlorostannate salt) was condensed with benzoic acid and with benzil to give, respectively, a 68% yield of 5,7,7-trimethyl-6-methylene-6,7-dihydro-5 7/-pyrrolo[2,3-/]-benzimidazole (37) and a 62% yield of 6,8,8-trimethyl-7-methylene-2,3-diphenyl-7,8-dihydro-6 7/-pyrrolo[2,3-g]quinoxaline (38).42 Spiropyrans from these linearly annellated Fischer s bases were not reported they likely would color upon irradiation with blue light. 

Selective polyimide membranes, (I), for helium, carbon dioxide, and oxygen were previously prepared by the author [1] by condensing 4,4 -(hexafluoro-isopropylidene) diphthalic anhydride with a 3 2 ratio of 2,4,6-trimethyl-1,3-phenylene diamine and diamino benzoic acid, respectively. 

Among metabolites in humans the following were identified 4-amino- and 6-aminodmitrotpluene, tetranitroazoxy toluene, 2 hydroxyIamino-4.6-diniirO toluene, 2,4 diamino-6-nitro- and 2,6-diamino-4 niuotoluene, 2,4,6-trini(ro-benzoic acid. A former finding that TNT is toxic to fish has been confirmed. 

Several methods are available for the colorimetric or flourometric determination of total DNA. The first two that will be considered involve depurination of DNA under acidic conditions, and are followed by chemical reactions with 3,5-diamino-benzoic acid (DABA) or diphenylamine (DPA). Two fluorescence methods based on selective, noncovalent interactions of a probe molecule with DNA will then be considered. 

An example of side-chain SLCPs whose mesogen consists of part of the main-chain as well as the side chain (Fig. 3h) has been reported by Kato et al. [107]. In this case the hydrogen bond mesogenic motif utilized was a benzoic acid (as part of the small molecule side chain 42) with a 2,6-diamino-... 

C—Prepared by reaction or 4.4 -bexafluoroisopropylidenediphihalic anhydride with 3.5-diamino benzoic acid. 

Diamino-6-hydroxymethylpteridine (VIII. 155) [302,303] was brominated with dibromotriphenylphosphorane essentially as described by Piper and Montgomery [247], but isolation and purification of 2,4-diamino-6-bromome-thylpteridine hydrobromide ((VIII.156) - HBr) was omitted in favour of condensing the bromide in situ with 4-(V-methylamino)benzoic acid to obtain... 

Polynaphthylimide with iV-naphthylimide orfho-sutetituents was prepared by the reaction of 3,3 -diamino-4,4 -di(p-aminophenoxy) diphenyl sulfone [164] with an equimolar amount of bis(naphthalic anhydride) followed by treatment with a two-fold molar amount of naphthalic anhydride in a m-cr ol-benzoic acid medium under the conditions of high-temperature catalytic polycondensation. The polymer was soluble in phenolic, amide solvents as well as in tetrachloroethane its molecular mass was of the order of 60 000, the softening temperature 340 °C and the temperature of 10 % mass loss 480 °C (Table 16). 

Fig. 5 Class B SPs. 10 Schemes for (a) closed low-MW assemblies (b) side-chain polymers and (c) multichain assemblies 11 supermolecule of 4-butoxybenzoic acid and stil-bazole " 12 supermolecule of derivatives of 2.6-diamino-pyridine and uracil 13 poly aery late with hexyloxy benzoic acid side chains H-bonded to stilbazole. " ...

CA Index Name Benzoic acid, 2-(3,6-diamino-9//-xanthen-9-yl)-, methyl ester... 

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