Benzodiazepines as anxiolytics

Hoffmann-La Roche tests benzodiazepines as anxiolytics (Librium, Valium)... 

Actions at benzodiazepine receptors are thought to underlie virtually all the pharmacological actions of the benzodiazepines, those that are desirable as well as those that are undesirable. This includes the desirable therapeutic actions of benzodiazepines as anxiolytics and sedative-hypnotics, as well as anticonvulsants and muscle relaxants. It also includes their undesirable side effects as amnestic agents and as agents that cause adaptations at the benzodiazepine receptor with chronic administration, which are thought to underlie the production of dependence and withdrawal from these agents (see Chapter 13). 

Madder SA, Schweizer E. Benzodiazepines as anxiolytic agents the risks of long-term treatment. Hospital Practice 1992 September 30, 109-16. 

Summary of product characteristics for benzodiazepines as anxiolytics or hypnotics (Eudralex Vol. Ill BC1A). 

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