Benzodiazepine-2,5-diones by Ugi-4CR with Convertible Isocyanides and UDC

Another example was reported by Ugi and co-workers in a study concerning the synthetic applications of convertible (jS-isocyanoethyl)alkyl carbonates [7a]. A solid-phase extension of the same procedure has been reported by the Kennedy group [20] at Array BioPharma who employed the resin-bound carbonate convertible isocyanide. 

A solid-phase extension of the UDC strategy for the preparation of highly pure and diverse arrays of l,4-benzodiazepine-2,5-diones has been reported. The method employed Wang resin-bound a-amino adds [75]. Another interesting solid-phase synthesis of l,4-benzodiazepine-2,5-diones was reported by Chen et al. [18b] that employed the Rink-isocyanide resin as the convertible isocyanide. 

Faggi et al. [86] reported a different approach. The Ugi-4CR between 4-chloro-2- 

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