Array Biopharma

K. Koch, Fourteenth International Conference of the Inflammation Research Association, October 15-19, 2006, Cambridge, MD, USA, Abstract SA40. [Arthritis Rheum. 2006, 54 (Suppl.), Abstr. 794] The slides are available on Array Biopharma Inc. company website www. arraybiopharma.com... 

John E. Robinson Array BioPharma 3200 Walnut Street Boulder CO 80301 USA... 

Array BioPharma, Inc., 3200 Walnut Street, Boulder, CO 80301, USA ewallace arraybiopharma.com... 

The Kennedy group at Array BioPharma described an elegant synthesis of 2,5-diketopiperazines employing the resin-bound carbonate convertible isocyanide (CCI resin see Scheme 2.9) [20], Ugi products 133 were converted into esters 134 and then deprotected and transformed into diketopiperazines 135 (Scheme 2.48). 

Another example was reported by Ugi and co-workers in a study concerning the synthetic applications of convertible (jS-isocyanoethyl)alkyl carbonates [7a]. A solid-phase extension of the same procedure has been reported by the Kennedy group [20] at Array BioPharma who employed the resin-bound carbonate convertible isocyanide. 

Robert Kirk DeLisle Scientific Computing/Bioinformatics, Array BioPharma Inc., Boulder, CO, USA... 

Optimer Building Blocks, Array Biopharma Bolder, CO, http //www. arraybiopharma.com. 

Amersham Pharmacia Biotech Array BioPharma Dharmacon Research, Inc. 

We thank the National Institutes of Health (GM48498), and Array Biopharma for financial support of this research. We also wish to thank Dr. T. Brian Hurley for helpful discussions and for initial work in our labs which prompted us to study the halogcn-dance reaction. Eric Stangeland is a recipient of a graduate fellowship from Pharmacia. 

Independent efforts by the Piscopio, Lee, and Porco groups at Array Biopharma, the University of Wisconsin, Madison, and Boston University, respectively, also laid the base for further development of relay metathesis. In the first of these reports, the RRCM concept was presented as shown in Scheme 9.3 [6]. 

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