Benzo pyrene bioaccumulation

Driscoll SK, AE McElroy (1996) Bioaccumulation and metabolism of benzo[a]pyrene in three species of polychaete worms. Environ Toxicol Chem 15 1401-1410. 

Landrum, P.F., B.J. Eadie, W.R. Faust, N.R. Morehead, and MJ. McCormick. 1984. Role of sediment in the bioaccumulation of benzo[a]pyrene by the amphipod, Pontoporeia hoyi. Pages 799-812 in M. Cooke and A.J. Dennis (eds.). Polynuclear Aromatic Hydrocarbons Mechanisms, Methods and Metabolism. Battelle Press, Columbus, OH. 

Penry, D.L. and D.P. Weston. 1998. Digestive determinants of benzo[a]pyrene and phenanthrene bioaccumulation by a deposit-feeding polychaete. Environ. Toxicol. Chem. 17 2254-2265. 

As discussed above, lipophilicity is a major determinant of the bioaccumulation potential of a chemical. However, lipophilic chemicals also have greater propensity to sorb to sediments, thus rendering them less available to bioaccumulate. For example, sorption of benzo[a]pyrene to humic acids reduced its propensity to bioaccumulate in sunfish by a factor of three. Fish from oligotrophic lakes, having low suspended solid levels, have been shown to accumulate more DDT than fish from eutrophic lakes that have high suspended solid contents. 

Benzo(a)- pyrene (PAH) Carcinogenic Mutagenic Teratogenic H Bioaccumulation H L H H... 

Xu CQ, Pan LQ, Liu N, Wang L, Miao JJ (2010) Cloning, characterization and tissue distribution of a pi-class glutathione S-transferase from clam (Venerupis phUippinarum) response to benzo[alpha]pyrene exposure. Comp Biochem Physiol C Toxicol Pharmacol 152 160-166 Yakan SD, Henkelmann B, Schramm KW, Okay OS (2011) Bioaccumulation depuration kinetics and effects of benzo(a)anthracene on MytUus galloprovincialis. Mar Pollut Bull 63 471-476 Yim UH, Oh JR, Hong SH, Lee SH, Shim WJ, Shim JH (2002) Identification of PAHs sources in bivalves and sediments 5 years after the Sea Prince oil spill in Korea. Environ Forensic 3 357-366... 

Studies on PAHs are largely conducted with specific compounds. For example, many studies that explore the uptake and elimination of PAHs in marine organisms deal with naphthalenes, a major component of petroleum, and carcinogenic PAHs, such as benzo[a]pyrene. Petroleum spills are important acute events hence, it is important to understand the processes that control the bioaccumulation of naphthalene and related compounds. Understanding the mechanics of chronic exposure to PAHs from urban areas is also desirable when assessing the population structure of marine organisms and the possibility of contaminant transfer to humans. Additionally, the carcinogenicity of PAHs is an important concern because some PAHs are biotransformed to reactive metabolites that can interact with DNA. 

---