Benzo fluoren-10-ones

Palladium-charcoal can also be used as catalyst for hydrogenation of carbonyl compounds For instance, 5-methyl-ll/f-benzo[ ]fluoren-11-one is reduced to the corresponding fluorenol in very good yield at room temperature, with absorption of one equivalent of hydrogen.401... 

We employed various substrates to check for MFO in two bivalve species, a salt water mussel (Mytilus edulis) and a fresh water clam (Anodonta sp). Cytochrome P-450 was also studied. Organisms were exposed to 100 PPM Venezuelan crude in a stagnant system for up to one month. Enzyme assays were carried out with digestive gland 9000 g homogenates (17) and cytochrome P-450 analysis, with microsomes (21). The hydrocarbon substrates investigated included 1I+C-labelled benzo(a)pyrene, fluorene, anthracene, and naphthalene. The method used for separation of BP metabolites by thin layer radiochromatography has been described (7). The metabolite detection method for the other aromatic hydrocarbons was essentially the same except methylene chloride was used as metabolite extractant as well as TLC developer. Besides the hydrocarbon substrates, we also checked for other MFO reactions, N-dealkylase with C-imipramine (22) and 0-dealkylase with ethoxycoumarin (15). 

Note Technical grades of naphthalene may contain one or more of the following impurities acenaphthene, benzo[6]thiophene, carbazole, chrysene, fluoranthene, fluorene, naphthacene, phenanthrene, pyrene, pyridine, and tetrazene. 

Preparation of 3-methoxy-6-(2- methyl-[2-(3-methoxy-7-oxo-7H-5,9-diaza-benzo[c]fluoren-6-ylamino)-ethyl]-amino -ethylamino)-5,9-diaza-benzo[c]fluoren-7-one... 

A mixture consisting of 6-chloro-3-methoxy-5,9-diaza-benzo[c]fluoren-7-one (21 mg), A-methyl-2,2 -diaminodiethylamine (3.3 mg), and K2C03 (10 mg) was suspended in 0.5 ml DMF and stirred 13 hours at 90°C, then concentrated. The residue was purified by chromatography on silica gel using CH2Cl2/methyl alcohol,... 

The preparation of the Step 1 co-reagent, 6-chloro-3-methoxy-5,9-diaza-benzo[c]fluoren-7-one, (II), by Aoyama (1) is illustrated in Eq. 2. The effectiveness of these derivatives, (III), against HCT116 cells is provided in Table 2. 

Jaworski [92] has found that E° of perylene and fluoren-9-one are independent of the acceptor number, as opposed to formal potentials of anthracene and benzo-quinone, which exhibit a linear dependence on the ACN of the used solvents. The... 

Fifty-four PAHs have been identified at one or more NPL hazardous waste sites. These 54 are acenaphthene, acenaphthylene, 2-acetoaminofluorene, anthracene, 9,10-anthracenedione, benz[a]anthracene, benzo[a]pyrene, benzo[e]pyrene, benzo[a]fluoranthene, benzo[b]fluoranthene, benzo[b]fluorene, benzofluoranthene, benzo[j]fluoranthene, benzo[k]fluoranthene. benzo[g,h,i]fluoranthene, benzoperylene, benzo[g,h,i]perylene, benzophenanthrene, benzopyrene, benzothiophene, benzo[b]thiophene, chrysene, 4H-cyclopenta[d,e,f]phenanthrene, dibenz[a,j]anthracene, dibenz[a,h]anthracene, 7,12- dimethylbenz[a]anthracene,... 

With respect to further PACs analysed in the sediment core (see Tab. 1), concentration profiles very similar to the one of benz[a]anthracene were detected for most of the substances. This group of polycyclic aromatic hydrocarbons (PAHs) include acenaphthylene, anthracene, chrysene, fluoranthene, phenanthrene, fluorene and pyrene. Only for perylene the distribution within the sediment core resembled the ones of benzo[a]pyrene and benzo[x]fluoranthene (x = b,k). 

Scholl reactions generally lead to six-membered rings but a few cases have been reported where five-membered rings were formed, particularly from ketones that carried a hydroxyl or an alkoxyl group para to the carbonyl group, such a case was reported by Fierz-David and Jaccard275 who found that 4-hydroxy-1-naphthyl phenyl ketone (and its methyl ether) gave 5-hydroxy-benzo[a]fluoren-l 1-one and not 4-hydroxybenz[de]anthrone ... 

An efficient, one pot method for the synthesis of benzo[f ]fluoren-10-ones was achieved by CSjCOj promoted sequential deprotonation and cyclization. The benzofuran ring was generated by an intramolecular acylation of an enolate <01TL8429>. 

---