Benzimidazole 2-arylamino

Bendale, P.M. and Sun, C.-M., Rapid microwave-assisted liquid-phase combinatorial synthesis of 2-(arylamino)benzimidazoles, /. Comb. Chem., 2002, 4, 359-361. 

A library of 2-(arylamino)benzimidazoles was prepared in a microwave-accelerated cyclocondensation of PEG-supported orffto-phcnylenediamines 31 with isothiocyanates, followed by the product cleavage from polymer support [55,56]. The quantitative cyclization required either microwave heating (in an open vessel system) for 10 min or reflux in MeOH for 4 hours (Scheme 20). The use of a soluble PEG matrix substantially simplified the... 

A solid phase synthesis of 2-arylamino-6H-pyrano[2,3-f]benzimidazole-6-ones is accomplished by reacting polymer bonded o-dianilino intermediates with arylisothiocyanates and diisopropylcarbodiimide." ... 

FIGURE 11.83 Solid-phase synthesis of psoralen analogs. (From Song, A., Zhang, J., and Lam, K.S., Synthesis and reactions of 7-fluoro-4-methyl-6-nitro-2-oxo-27f-l-benzopyran-3-carboxylic acid a novel scaffold for combinatorial synthesis of coumarins, J. Comb. Chem., 6,112, 2004 Song, A. et al.. Solid-phase synthesis and spectral properties of 2-alkylthio-6//-pyrano[2,3-/ benzimidazole-6-ones a combinatorial approach for 2-aUcylthioimidazo coumarins, J. Comb. Chem., 6, 604, 2004 Song, A. and Lam, K.S., Parallel sohd-phase synthesis of 2-arylamino-6H-pyrano [2,3-f] benzimidazole-6-ones, Tetrahedron, 60, 8605, 2004.)... 

Varying degrees of vitro antifungal activity have been claimed for a variety of chemical types. Among these are substituted 8-hydroxyquino-lines,J 2 acetylenic con5>oun, 3 2-fluorofatty acids,alkyl phenyl sulfides,aryl thiocyanates,substituted phenylhydrazines and phenyl-pyrazolones methyl-5-(3,3-dimethyl-l-triazeno)imidazole- -carboxylate p-hydroxypropiophenone,50 substituted benzimidazoles,51 2,U-bis(arylamino)-5-methylpyrimidines52 and isothiocyanates.53... 

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