2.4- Dimethoxy benzaldehyde

N]04Ci,H2, Benzaldehyde, 2,3-dimethoxy-, 5-(a-methylbenzyl)semioxamazone, chromium complexes, 23 88 Nj04C H2, Benzaldehyde, 3,4-dimethoxy-, 5-(ot-methylbenzyl)semioxamazone, chromium complexes, 23 88 N305C,Hi3, Cytidine, palladium(II) complexes, 23 54 N30,3PrC8H,6, Praseodymium Ill), trini-... 

H.57) Benzaldehyde, 3,4-dimethoxy-, 3,4-dimethoxybenzaldehyde, veratraldehyde, methylvanillin, protocatechualdehyde dimethyl ether 1120-14-9] FEMA 3109... 

Benzaldehyde, 3,4-dimethoxy- veratraldehyde 172a 174a, 174b, 603, 3370... 

A second, less well-known example is the anodic conversion of toluenes in methanol as solvent to benzaldehyde-dimethoxy acetals (180, 7S7) ... 

Raney Nickel W2 or W4, EtOH, 85-100% yield. Mono- and dimethoxy-substituted benzyl ethers and benzaldehyde acetals are not cleaved under these conditions, and trisubstituted alkenes are not reduced. 

Dimethoxy-benzaldehyd-2,4-dinitro-phenylhydrazon2 Einc Losung von 1,14 g (5,7 mMol)... 

Paired electrosynthesis of phthalide and p-fert-butyl benzaldehyde (Putter and Hannebaum, 2000) and 2,5 Dimethoxy-2,5-dihydrofuran from furan (Steckhan et al, 2000)... 

Ethanone, 1- [3-(l,l-dimethylethyl)-4-methoxy-5-nitrophenyl Benzaldehyde, 2 (l,l-dimethylethyl)-4-methoxy-5-nitro Benzene, 1,4-BIS- (1, l-dimethylethyl)-2 methoxy-5-nitro Benzene, 1-(1, l-dimethylethyl)-2, 5-dimethoxy-4-nitro Benzene, 1-(1, l-dimethylethyl)-2-methoxy-4 methyl-5-nitro Benzaldehyde, 5- (1, l-dimethylethyl)-2-methyl-3-nitro Benzaldehyde, 2- (1, l-dimethylethyl)-4,5,6-trimethyl-3-nitro Benzene, 5-(l, l-dimethylethyl)-2-methoxy-l, 3-dinitro Benzene, 1-(1, l-dimethylethyl)-4-methoxy-2-methyl 3-5-dinitro Benzene, 2-bromo-5- (1, l-dimethylethyl)-4-methoxy-l,... 

The 9-catalyzed Mukaiyama-aldol reaction [74] of benzaldehyde and 1,2-dimethoxy benzaldehyde with a ketene silyl acetal in the presence of 10mol% thiourea 9 furnished the target product in low yield (36%), while the same reaction... 

Multi-step syntheses of a radiopharmaceutical involving an aromatic nucleophilic radiofluorination An example of a multi-step radiosynthetic pathway is the no-carrier-added synthesis of 6-[ F]fluoro-L-DOPA (Scheme 45). The first step involves the preparation of 4,5-dimethoxy-2-[ F]fluorobenzaldehyde from the corresponding nitro-substituted benzaldehyde. The following steps involve its condensation with an asymmetric chiral inductor [206] followed by L-selectride reduction of the... 

Growth conditions in deep-well microtiter plates were optimized with respect to optimal expression of active enzymes (Fig. 2.2.1.1). The best results were obtained with an expression time of 20 h at 37 °C (Fig. 2.2.1.1, lanes 7-9). Subsequently, E. coli cells were enzymatically disrupted by lysozyme treatment, and the carboligase activity was monitored by a modified tetrazolium salt color assay [16], This color assay is based on the reduction of the 2,3,5-triphenyltetrazolium chloride (TTC) 13 to the corresponding formazan 15, which has an intense red color (Fig. 2.2.1.2A). Before screening ofa BFD variant library, substrates and products were tested in the color assay. Neither substrate, benzaldehyde 4 nor dimethoxy-acetaldehyde 8, reduced TTC 13 however, the product 2-hydroxy-3,3-dimethoxy-propiophenone 10 already caused color formation at low concentrations of 2.5-10 mM (Fig. 2.2.1.2B). Benzoin 12 as the product also gave a color change at a similar concentration (data not shown). 

To a solution of 41.6 g. (0.25 mole) of purified 2,3-dimethoxy-benzaldehyde (Note 1) in 150 ml. of 95% ethanol is added 23.4 g. (0.75 mole) of methylamine in 50 to 75 ml. of water (Note 2). The mixture is heated to boiling and placed in a 500-ml. heavy-walled bottle (Note 3), and 6 g. of Raney nickel catalyst is added (Note 4). The bottle is connected to a low-pressure hydrogenation apparatus, the system is flushed with hydrogen, and the mixture is shaken with hydrogen at an initial pressure of 45 lb. until 0.25 mole of hydrogen is absorbed and the absorption ceases (Note 5). 

SYNTHESIS A solution of 2.3 g 2,5-dimethoxy-4-(methylthio)benzaldehyde (see under 2C-T for its synthesis) in 7.5 mL nitroethane was treated with 0.45 g anhydrous ammonium acetate and heated on the steam bath for 6 h. The excess... 

The three-carbon amphetamine analogue of 2C-F would quite logically be called DOF (2,5-dimethoxy-4-fluoroamphetamine). It has been prepared by reaction of the above benzaldehyde with nitroethane (giving l-(2,5-dimethoxy-4-fluorophenyl)-2-nitropropene, with a melting point of 128-129 °C from ethanol) followed by LAH reduction to DOF (the hydrochloride salt has a melting point of 166-167 °C, after recrystallization from ether/ethyl acetate/ethanol). Animal studies that have compared DOF to the highly potent DOI and DOB imply that the human activity will be some four to six times less than these two heavier halide analogues. As of the present time, no human trials of DOF have been made. 

A solution 3.7 g 2,5-dimethoxy-3,4-(trimethylene)benzaldehyde in 15 g nitromethane was treated with 0.7 g anhydrous ammonium acetate and heated on the steam bath for 14 h. The volatiles were removed under vacuum, and the residue set up to 3.5 g dark crystals, which melted broadly between 126-138 °C. Recrystallization of the entire mass from 70 mL boiling EtOH gave 3.2 g burnished gold crystals with a mp of 129-137 °C. A further recrystallization of an analytical sample fromMeOH gave 2,5-dimethoxy-3,4-(tri me thylene)-B-nitiostyreneas yellow crystals with a mp of 146-147 CC. Anal. (C13H,5N04) C,H. 

A mixture of 22 g 2,5-dimethoxypropylbenzene, 23 g POCl3 and 22 g N-methylformanilide was heated on the steam bath for 1.5 h. The hot, dark reaction mass was poured into 1 L H20, which allowed the eventual separation of 2,5-dimethoxy-4-(n)-propylbenzaldehyde as a clear yellow oil weighting 14 g. Although the homologous 4-ethyl and 4-butyl benzaldehydes were clean crystalline solids, this propyl homologue remained an oil. Gas chromatographic analysis showed it to be about 90% pure, and it was used as obtained in the nitrostyrene steps with either nitromethane (here) or nitroethane (under DOPR). 

To a solution of 6.7 g 2,5-dimethoxy-(i-propylthio)benzaldehyde in 40 g of nitromethane there was added 0.10 g of anhydrous ammonium acetate, and the mixture was heated on the steam bath for 2 h. The excess reagcnt/solvent was removed under vacuum yielding 8.9 g of orange solids. This was recrystallized from 200 mL boiling MeOH providing 6.2 g of 2,5-dimethoxy-B-nitro-4-(i-propyT thio)styrene as lustrous golden orange platelets. 

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