Benomyl structure

Benomyl induced aromatase activity in a human ovarian tumor cell line. Benomyl does not cause mutations or structural chromosomal aberrations in somatic or germ cells. Benomyl does not interact directly with DNA in mammalian or nonmammalian systems. Benomyl causes chromosomal aberrations (aneuploidy and/or polyploidy) both in vitro and in vivo due to disruption of microtubules. Benomyl is not clasto-genic, however. 

The continuous use of o-phenylphenol, biphenyl, thiabendazole, benomyl, and sec-butyl amine for 20 years to control postharvest decay of citrus fruits has resulted 1n a serious problem of fungicide-resistance in Peniclllium digitatum and P. italicum. Fungicide-resistant Perilc1111 um Isolates are cross-resistant to structurally-related compounds and, 1n addition, may be resistant to two or more unrelated compounds. Biotypes of P. digitatum resistant to imazalil have been found recently in 19 packinghouses throughout California. 

The triazine derivative is mentioned under carbamates, as it originates from Benomyl (11.5.) and at pH >13 intermediarily hydrolizes to an unstable carbamic acid which after elimination of CO2 stabilizes to l-(2-benzimidazolyl)-3-n-butylurea (Chiba Singh, 1986) structural formula ... 

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