Beneficial Effects of Degenerate Metathesis

With synthetic access to pure samples of both diastereomers of chiral-at-metal catalyst 11, the abihty of each diastereomer to selectively effect enantioselective 

Inversion at the metal center can be accomplished by any complete metathesis event. To probe whether the catalytically relevant epimerization event was substrate-based, a set of isotopic exchange experiments was performed 

For a related discussion for ring-opening cross metathesis reactions, see Bencze, 

Mechanisms of Olefin Metathesis Catalyst Decomposition and Methods of Catalyst Reactivation 

Handbook of Metathesis Vol 1 Catalyst Development and Mechanism, Second Edition. 

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