Behavior sensorimotor gating

Melatonin receptor (MT1) knockout mice display depression-like behaviors and deficits in sensorimotor gating. Brain Res. Bull. 68, 425-9. 

Chen YJ, Johnson MA, Lieberman MD, Goodchild R, Schobel S, et al. 2007. Type III Neuregulin-1 is required for normal sensorimotor gating, memory related behaviors and cortico-striatal circuit components. J Neurosci (in press). 

Like the pharmacological model presented above, a genetic model also targets the NMDA receptor. This model was created by knocking down the NRl subunit of the NMDA receptor, which is obligatory for receptor function, in mice so that only 5% of the protein is expressed (117). These animals, also known as NRl hypomorphs, show NMDA receptor hypofunc-tion and display several schizophrenia-like behaviors, such as reduced social interactions, increased locomotion, stereotypic movements, and sensorimotor gating deficits (117, 118). Interestingly, treatment of these mice with the atypical antipsychotic... 

Duncan GE, Moy SS, Perez A, Eiddy DM, Zinzow WM, Lieber-man JA, Snouwaert JN, Roller BH Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor function. Behav. Brain Res. 2004 153 507-19. 

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