Base pair hydrogen bond interactions

The nucleic acids known as deoxyribonucleic acid (DNA) are the molecules that store genetic information. This information is carried as a sequence of bases in the polymeric molecule. Remarkably, the interpretation of this sequence depends upon simple hydrogen bonding interactions between base pairs. Hydrogen bonding is fundamental to the double helix arrangement of the DNA molecule, and the translation and transcription via ribonucleic acid (RNA) of the genetic information present in the DNA molecule. 

At higher concentrations they also interact with the nucleic acid bases so that they can even destroy the base pair hydrogen bonding, and compromise the structural integrity of the nucleic acid polymers [90-92]. 

Interestingly, the G-N3 site has been shown to be involved in G-C base pairing should N7 and N1 be unavailable (72). This type of hydrogen-bonding interaction is also frequently observed in the packing of guanine derivatives in the solid state, including metal derivatives (56,73). 

That way, the Distributed Electrostatic Moments based on the ELF Partition (DE-MEP) allows computing of local moments located at non-atomic centres such as lone pairs, a bonds and n systems. Local dipole contributions have been shown to be useful to rationalize inductive polarization effects and typical hydrogen bond interactions. Moreover, bond quadrupole polarization moments being related to a n character enable to discuss bond multiplicities, and to sort families of molecules according to their bond order. 

DNA structure. The hydrogen-bonding interaction of the AT base pair was previously described from XRD analysis by Hoogsteen on a single crystal grown from aqueous solution (Fig. 2a) [30]. Etter et al. reported that grinding A and... 

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