Base cream for extemporaneous preparations

Heat a mixture of items 1-5 and the water separately to about 80°C. 

With rigorous stirring, add the water to the obtained solution. 

Heat items 7 and 8 until the active ingredient is dissolved, mix with aqueous solution, and continue to stir during cooling to room temperature. 

This white basic cream can be readily used for active ingredients soluble in 1,2-propylene glycol. 

Handbook of Pharmaceutical Manufacturing Formulations Semisolid Products 

---