Basal lamina heparan sulfate

Basal laminas are specialized areas of the ECM that surround epithelial and some other cells (eg, muscle cells) here we discuss only the laminas found in the renal glomerulus. In that strucmre, the basal lamina is contributed by two separate sheets of cells (one endothelial and one epithelial), each disposed on opposite sides of the lamina these three layers make up the glomerular membrane. The primary components of the basal lamina are three proteins—laminin, entactin, and type IV collagen—and the GAG heparin or heparan sulfate. These components are synthesized by the underlying cells. 

Perlecan 600,000 Heparan sulfate 2-15 Basal laminae Structural and filtering function in basal lamina... 

Eldridge, C.F., Sanes, J.R., Chui, A.Y., Bunge, R.P. and Cornbrooks, C.J. (1986) Basal lamina-associated heparan sulfate proteoglycan in the rat peripheral nervous system ... 

The basal lamina surrounding the abluminal surface of the endothelial cell is composed of type IV collagen, heparan sulfate, fibronectin, and laminin. Laminin acts as a charge barrier and interacts with integrins to regulate permeability of the BBB and cellular transport across it [5]. 

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