Basal ganglia circuit

Alexander, G. E. and Crutcher, M. D. Functional architecture of basal ganglia circuits Neural substrates of parallel processing. Trends Neurosci. 13 266-271,1990. 

Fig. 10 Regulation of the striatopallidal indirect GABAergic pathway A2A receptor-mediated dual excitatory modulation of the indirect pathway. Presumed action of the nondopamineigic adenosine receptor ligand in the basal ganglia circuit. Adenosine A(2A) receptors are localized to the indirect striatal output function (courtesy of Mori and Shindou, 2003)...

This latter conclusion has important implications in the context of the functional organization of the striatum, and in particular with the concept of parallel functional cortical-basal ganglia circuits as put forth by Alexander and his colleagues (Alexander and Crutcher 1990 Alexander et al. 1986, 1990). The basis of the matrisome concept is that the mulitple innervation zones provided from a single cortical site, represent functional units in which cortical information is reorganized. Such discontinuous patterns of corticostriatal inputs are clearly established from a number of studies employing a variety of tracers in a number of species over an extended period of time. However, the basis of such patterns is still open to study. 

SUMMARY OF ORGANIZATION OF CORTICO-BASAL GANGLIA CIRCUITS... 

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