Barbituric add

Barbituric add 374 condenses at 125-145 °C with N,N-bis(trimethylsilyl)formamide 22 c in unspecified yield [137] to give 375, which is, however, also obtained, in quantitative yield, by heating free barbituric acid 374 in formamide for 1 h at 130°C [137a]. N-Ethylrhodanines 376 and 2-methyl-N-ethyl-benzothiazole tosylate 378 react with 22c to give the dimers 377 and 379 in 55 and 75% yields, respectively [137] (Scheme 4.51). 

Preparation 405.—Veronal, Baxbitone (Diethylmalowyl urea, 5 5-diethyl-barbituric add). 

Barbituric add — see also Pyrimidine-2,4,6-trione, perhydro-acidic pJCa, 3, 60 bromination, 3, 70 fluorination, 3, 70 structure, 3, 68 tautomerism, 2, 27 in thermography, 1, 392 Barbituric acid, N-alkyl-chlorination, 3, 70 Barbituric acid, 5-aminomethylene-synthesis, 3, 524 Barbituric acid, 5-arylidene-pyridopyrimidines from, 3, 227 Barbituric acid, 1,3-dicyclohexyl-synthesis, 3, 113 Barbituric acid, 2-thio-sensitizing dye... 

Cyanoguanidine is used in fertilizers as a stabilizer of NC in org synthesis of mela-imne, barbituric add guanidifie Saits in pharmaceutical products dyestuffs and in espls. Some examples of espls contg cyano ... 

Internal standard tolybarb (5-ethyl-5-(p-methylphenyl)barbituric add) (4.89) Limit of detection 500 ng/mL... 

McKeown RH, First thermodynamic dissociaticHi ccmstants of 5,5-disubstituted barbituric adds in water at °C Part 1, JCS. Perkin II, 504 514 (1980). 

Spectro f = 25.0 0.02 disubstituted barbituric adds in water at25 °C. Part 1,/CS. Perkin II,... 

A solvent-free one-pot reaction of a mixture of Meldrum s acid or barbituric add derivatives 814, urea, and aldehyde under MWI in the presence of acetic add gave, stereoselectively, heterobicyclic compounds 815 within 4 min in good yields (70-83%) (Scheme 155). The procedure also avoided problems connected with solvent use times were reduced from several hours to few minutes (04TL2575). 

Ethyl-5(l,3- dimethylbutyi)barbituric add ( + ) Convulsant (—) Depressant ( ) Convulsant Hof and Adron-Hanls. ... 

N, O, C, H only (26) Oxazole, lactams, barbituric add, hydantoin, prolyl... 

The first step of the domino process again was the laccase-catalyzed oxidation of catechol 25 to o-quinone 26, which reacted through Michael addition with N,N-dimethyl barbituric add 31 to yield the intermediate 32. This compound underwent a further oxidation followed by cyclization through two Michael additions. Finally, laccase-catalyzed oxidation provided polycyclic dispiropyrimidinone 35 in excellent yield of 90% (Scheme 9.7). Recently, the same authors reported the synthesis of... 

Since its discovery by Baeyer violuric acid (II) has been of perennial interest to chemists, largely on account of the beautifully colored salts which it forms. Baeyer prepared this substance by the action of nitrous acid on barbituric add (I), while Ceresole showed that it could be produced by the action of hydroxylamine hydrochloride on alloxan (HI). 

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