Band-target entropy minimization BTEM

Since a larger sample volume is presumed to be probed, the use of transmission mode has led to simpler, more accurate models requiring fewer calibration samples [50]. Scientists at AstraZeneca found that with a transmission Raman approach as few as three calibration samples were required to obtain prediction errors nearly equivalent to their full model [42]. For a fixed 10-s acquisition time, the transmission system had prediction errors as much as 30% less than the WAI system, though both approaches had low errors. It is hoped that this approach in combination with advanced data analysis techniques, such as band target entropy minimization (BTEM) [51], might help improve Raman s quantitative sensitivity further. 

E. Widjaja, Devdopment of Band-Target Entropy Minimization (BTEM) and Associated Software Tools, PhD Thesis, National University of Singapore, 2002. 

Garland et al. have developed a powerful method for the reconstruction of individual pure component spectra from complex catalytic mixtures [20]. Using this band-target entropy minimization (BTEM) protocol, he was able to identify the mononuclear rhodium acyl intermediate in the hydroformylation reaction of 3,3-dimethylbut-l-ene starting from Rh4(a-CO)9(p-CO)3 as catalyst precursor [21]. In addition to the catalyst precursor and the more stable decomposition product... 

BTEM band target entropy minimization DAQ data acquisition... 

Tan et al. [166] present the potential of a new chemometric method (band target entropy minimization combined with multilinear regression, BTEM-MLR) for estimating the concentration maps of four significant components associated with cellular water, a-helical proteins, lipids, and spectral aberration in FPA images [166]. 

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