Band-target entropy minimization

1) Targeting is the term we have adopted whereby the user specifies a small spectral window, i. e. 1 cm in the vicinity of a local maximum or minimum. This constrains the 

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Since a larger sample volume is presumed to be probed, the use of transmission mode has led to simpler, more accurate models requiring fewer calibration samples [50]. Scientists at AstraZeneca found that with a transmission Raman approach as few as three calibration samples were required to obtain prediction errors nearly equivalent to their full model [42]. For a fixed 10-s acquisition time, the transmission system had prediction errors as much as 30% less than the WAI system, though both approaches had low errors. It is hoped that this approach in combination with advanced data analysis techniques, such as band target entropy minimization (BTEM) [51], might help improve Raman s quantitative sensitivity further. 

E. Widjaja and M. Garland, Use of Raman microscopy and band-target entropy minimization analysis to identify dyes in a commercial stamp. Implications for authentication and counterfeit detection. Anal. Chem., 80, 729-733 (2008). 

E. Widjaja, Y.Y. Tan and M. Garland, Application of band-target entropy minimization to on-line Raman monitoring of an organic synthesis. An example of new technology for process analytical technology, Org. Process Res. Dev., 11, 98-103 (2007). 

BTEM band target entropy minimization DAQ data acquisition... 

E. Widjaja, Devdopment of Band-Target Entropy Minimization (BTEM) and Associated Software Tools, PhD Thesis, National University of Singapore, 2002. 

Garland et al. have developed a powerful method for the reconstruction of individual pure component spectra from complex catalytic mixtures [20]. Using this band-target entropy minimization (BTEM) protocol, he was able to identify the mononuclear rhodium acyl intermediate in the hydroformylation reaction of 3,3-dimethylbut-l-ene starting from Rh4(a-CO)9(p-CO)3 as catalyst precursor [21]. In addition to the catalyst precursor and the more stable decomposition product... 

Tan et al. [166] present the potential of a new chemometric method (band target entropy minimization combined with multilinear regression, BTEM-MLR) for estimating the concentration maps of four significant components associated with cellular water, a-helical proteins, lipids, and spectral aberration in FPA images [166]. 

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