Bacterial synthesis factors influencing

XII. Factors Influencing Bacterial Synthesis in the Animal Organism.. . 30... 

A number of factors have been shown to influence the extent of this bacterial synthesis. The constituents of the diet proteins, fats, carbohydrates, and the different vitamins appear to play a significant part. The widespread use of bacteriostatic a nts (the sulfonamides), particularly in protracted therapy or prolonged prophylaxis, should obviously call for vigilance because of their action in suppressing synthesis of the various members of the B complex. 

Although the mechanism whereby proteins are synthesized is the same in all living forms, classical distinctions exist between eucaryal (post-transcriptional) and bacterial (co-transcriptional) translation. In-frame read-out of (usually polycistronic) bacterial mRNAs is established via Shine-Dalgarno mRNA 16S-rRNA recognition mechanisms polypeptide synthesis is initiated by a formylated methionine and the initiation reactions are assisted by a limited number of protein factors (three in Escherichia coli) that primarily influence kinetic parameters [3],... 

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