Bacterial infection passive immunization

Figure 12. Protective efficiency in mice of passively transferred rabbit antisera against intraperitoneal challenge with S. typhimurium bacteria (U 106 bacteria = 25 LD 0 dose). Percentage ofsurvivors plotted against ELISA titers with S. typhimurium LPS as antigen. Key U, anti whole heat-killed bacterial serum (04, 12 specific) a, anti[GM(A )R],-ITC-BSA serum (04,12) . anti[GM(A )R]2-ITC-BSA serum (04,12) and o, anti AM-ITC-BSA serum (04). (Reproduced with permission from Ref. 65. Copyright 1981, Infect. Immun.j...

Once an individual has become immune through previous infection, vaccination, or by passive transmission of maternal antibody, these specific defenses effectively control most viral and bacterial pathogens. Depletion of the CD4+ T-lymphocyte population, as occurs in acquired immunedeficiency syndrome (AIDS) leads to a general reduction in immune competence and an increased susceptibility to infectious and neoplastic disease (22). Similarly, IgA deficiency can result in increased risk of respiratory tract infection (23). 

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