Bacteria protein synthesis inhibitors aminoglycosides

Aminoglycoside prototype bactericidal inhibitor of protein synthesis (30S) active against many aerobic gram-negative bacteria. Narrow therapeutic window dose reduction required in renal impairment. Tox renal dysfunction, ototoxicity once-daily dosing is effective (postantibiotic effect) and less toxic. Amikacin and tobramycin are similar. 

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