Babesia bovis

By 1980, investigations on the molecular biology of malaria under the direction of David Kemp had begun. Two PhD students, Ross Coppel and Alan Cowman, were able to construct cDNA libraries with Ross working on P. falciparum and Alan on Babesia bovis. Work on P. falciparum was... 

Following invasion of their host cell, several intracellular parasites remain inside the parasitophorous vacuole which may or may not fuse with lysosomes. Other pathogens, such as Rickettsia spp. Listeria monocytogenes. Shigellaflexneri, Theileria parva, Babesia bovis and Trypanosoma cruzi must leave the phagocytic vacuole and establish themselves into the cytosolic compartment to survive successfully. Obviously, disruption of the phagocytic vacuole represents a critical step in this escape process (reviewed in ref. 34). The role of a hemolysin secreted by T. cruzi amastigotes is discussed in this section. 

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