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Azoles / imidazoles antifungal

Antifungal drugs are classified according to their mode of action and/or their chemical class. Four chemical classes have mainly contributed to the actual armentory of antifungal drugs the broadest class is the one of azoles (imidazoles and triazoles), followed by polyenes, allylamines and morpholines. Some individual compounds are used in dermatology. [Pg.131]

The azole derivatives for systemic administration include the imidazoles ketoconazole and miconazole and the triazoles fluconazole, itraconazole, posaconazole and voriconazole. They are broad spectrum antifungals and have activity against several dermatophytes, Candida, Cryptococcus and other fungi that cause deep-seated infections. [Pg.423]

Azole antifungal drugs are synthetic compounds with broad-spectrum fungistatic activity. Azoles can be divided into two groups the older imidazole agents, in which the hve-member azole nucleus contains two nitrogens, and the newer triazole compounds, fluconazole and itraconazole, in which the azole nucleus contains three nitrogens. [Pg.598]

Azole derivatives currently available for oral treatment of systemic mycosis include fluconazole (Diflucan), itraconazole (Sporonax), and ketoconazole (Nizoral). As discussed in Chapter 48 Antifungal Agents, imidazole derivatives act by affecting the permeability of the cell membrane of... [Pg.1448]

Ketoconazole [kee toe KON a zole], a substituted imidazole, is one of a family of azoles useful in treating systemic mycoses. In addition to its antifungal activity, ketoconazole also inhibits gonadal and adrenal steroid synthesis in humans by blocking C17-20 lyase, Up-hydroxylase, and cholesterol side-chain cleavage thus, it suppresses testosterone and cortisol synthesis. [Pg.351]

Ketoconazole was the first successful, oral, broad-spectrum azole antifungal. Ketoconazole is in the imidazole... [Pg.208]

See other pages where Azoles / imidazoles antifungal is mentioned: [Pg.39]    [Pg.92]    [Pg.127]    [Pg.131]    [Pg.179]    [Pg.286]    [Pg.62]    [Pg.72]    [Pg.1060]    [Pg.1110]    [Pg.282]    [Pg.4]    [Pg.131]    [Pg.235]    [Pg.3973]    [Pg.301]    [Pg.240]    [Pg.242]    [Pg.50]    [Pg.30]    [Pg.196]    [Pg.200]    [Pg.184]    [Pg.265]    [Pg.249]    [Pg.605]    [Pg.801]    [Pg.446]    [Pg.1727]    [Pg.1732]    [Pg.61]    [Pg.311]    [Pg.13]    [Pg.650]    [Pg.343]    [Pg.87]    [Pg.92]    [Pg.42]    [Pg.48]    [Pg.73]    [Pg.501]    [Pg.501]   
See also in sourсe #XX -- [ Pg.233 ]



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Azole antifungals

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