Ketoconazole Azelastine

Clinically important, potentially hazardous interactions with alcohol, antihistamines, azatadine, azelastine, brompheniramine, buclizine, chlorpheniramine, cimetidine, clemastine, dexchlorpheniramine, erythromycin, ketoconazole, meclizine, pizotifen, rifampicin, ritonavir... 

Ketoconazole raises the levels of desloratadine, emedastine, fexofenadine but as no adverse cardiac effects were seen these combinations are considered safe. No interaction occurs between ketoconazole and azelastine, cetirizine, intranasal levocabastine, and none is expected with levocetirizine. 

Azelastine 4 mg twice daily Ketoconazole 200 mg twice daily 7 12 healthy subjects Not determined. In vitro tests suggest no change likely. Not determined. In vitro tests suggest no change likely. No change 2... 

Morganroth J, Lyness WH, Perhach JL, Mather GG. Harr JE. Trager WF. Levy RH. Rosenberg A. Lack of effect of azelastine and ketoconazole coadministration on elec trocardiographic parameters in healthy volunteers. J Clin Pharmacol (1997) 37. 1065-72. 

Etesloratadine, emedastine and fexofenadine levels are raised by ketoconazole but because this does not result in adverse cardiac effects concurrent use is considered safe. Azelastine, cetirizine (and therefore probably... 

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