Azelastine hydrochloride nasal spray

Astelin nasal spray contains 0.1% azelastine hydrochloride in an aqueous solution at pH 6.8 0.3. It also contains benzalkonium chloride (125 mcg/mL), edetate disodium, 

Charge 90% of item 8 in a suitable stainless steel vessel. 

Dissolve in the following order azelastine hydrochloride, edetic acid, sodium chloride, benzalkonium chloride, citric acid, and sodium monohydrogen-phosphate, and mix well. 

Pass the solution through a membrane filter of pore size 0.22 microns. 

Fill in plastic bottles that are closed with a conventional spray insert or into plastic or glass bottles that are closed with a conventional pump sprayer. In the latter case, pumps with nasal spray inserts are, for example, used that spray about 0.14 mL of solution per actuation. In this manner, 0.14 mg of azelastine hydrochloride is sprayed into the nose per actuation in the form of the solution. 

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Q5 Azelastine hydrochloride is an antihistamine, an Hi receptor antagonist which is available as a nasal spray. 

AZELASTINE HYDROCHLORIDE (Astelin nasal spray 137 mcg/spray)... 

Azelastine (hydrochloride salt is ASTELIN, Meda Pharmaceuticals Inc.) is an antihistamine that is used as a nasal spray and provides reMef for seasonal allergies. 

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