Avascular osteonecrosis

A patient with psoriasis taking cielosporin and applying an average of betamethasone 30 mg daily (as 15 g to 150 g of topical betamethasone 0.05% cream or ointment) developed avascular osteonecrosis of the femoral heads of both hip joints. ... 

A 64-year-old man underwent a total hip arthroplasty for severe osteoarthritis of his left hip following avascular osteonecrosis. An SEM3 type (Science et Medecine, Montrouge, France) cementless forged Ti A16-4V alloy, with femoral stem size 12, coated with hydroxyapatite on the proximal third, with a metallic head of a diameter 28 mm, and an ultra-high molecular weight polyethylene (UHMWPE) insert (liner) with a metal acetabular cup (50 mm) was inserted. Four years after the operation, he developed severe pain in the left... 

Mouth - teeth Imaging and histology of bone and surroxmding mucosa Sweeks after cessation of chemotherapy containing bevacizumab showed avascular osteonecrosis of the mandible in a female patient with non-small cell lung cancer who experienced spontaneous teeth loss. Three months after withdrawal of bevacizumab, sequestration of the mandible with marked expansion of the mucosal vasculature began and spontaneous bone sequestration occurred a few months later followed by stable mucosal coverage [114 ]. 

In 15 men with osteonecrosis of the femoral head after short-term therapy the mean duration of therapy was 21 (range 7-39) days and the mean dose in milligram equivalents of prednisone was 850 (range 290-3300) mg (269). The time from administration of glucocorticoids to hip pain was 17 (range 6-33) months. A new case of bilateral avascular necrosis of the femoral heads after high-dose short-term dexamethasone therapy as an antiemetic in cancer chemotherapy has been reported (270). 

In the hip, avascular necrosis (osteonecrosis) has a characteristic double-line sign appearance. 

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