Autoimmunity protective

Studies from several laboratories have shown that T cells patrol the healthy CNS, but do not accumulate there. The recent data suggest that, in the event of an acute injury or chronic neurodegenera five condition, T cells are recruited by and accumulate in the CNS (Hirschberg et al., 1998 Moalem et al., 1999a), where they might rescue neurons from degeneration if the damage caused by the toxic biochemical environment is not yet irreversible moreover, the recruited T cells will prevent further deterioration. It is also possible that this autoimmune protective mechanism also operates when the... 

Schwartz, M. and Kipnis, J., Self and non-self discrimination is needed for the existence rather than deletion of autoimmunity The role of regulatory T cells in protective autoimmunity, Cell. Mol. Life Sci., 61, 2285, 2004. 

In autoimmunity models, similar interactions occur. Thus, mice exposed to S. mansoni ova are protected from two different autoimmune diseases, type 1 diabetes [71] and experimental allergic encephalomyelitis [72, 73]. In these instances, a Th2 immune deviation might equally explain the amelioration of Thl pathology, and experimental testing of this possibility remains to be undertaken. 

McGeachy MJ, Stephens LA, Anderton SM Natural recovery and protection from autoimmune encephalomyelitis contribution ofCD4+CD25+ regulatory cells within the central nervous system. J Immunol 2005 175 3025-3032. 

Cyclosporine A is the first drug to affect a specific line of protecting cells of the body. Unlike usual cytotoxics, it suppresses T-cells and acts on all cell lines simultaneously. Cyclosporine A significantly eases the reception of transplants, and increases the possibility of treating autoimmune system diseases. 

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