Autoimmune polyendocrine

Autoimmune hepatitis (AIH). Chronic autoimmune-mediated hepatic inflammation characterized by antinuclear (ANA), smooth muscle (SMA)/anti-F-actin, liver-kidney microsomal (LKM), and soluble liver antigen (SLA) antibodies. Autoimmune hepatitis constitutes 10-20% of all cases of chronic hepatitis, ft may be idiopathic (Alff type 1, 2, and 3), part of autoimmune polyendocrine syndrome type 1 (APECED hepatitis), or drug-induced. See also -liver-kidney microsomal antibodies, liver-specific antigens. 

Betterle C, Dal Pra C, Mantero F, Zanchetta R (2002) Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocrinol Rev, 23 327-364. 

Bottazzo GF, Florin-Christensen A, Doniach D (1974) Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet, 2(7892) 1279-1283. 

Seissler. J., M. Schott, H. Steinbrenner, P. Peterson, and WA. Scherbaum (1999). Autoantibodies to adrenal cytochrome P450 antigens in isolated Addison s disease and autoimmune polyendocrine syndrome type 11. Exp. Clin. Endocrinol. Diabetes 107, 208-213. 

S. Laureti, F. Forini, A. Cosentino et al. (2000). Autoantibodies against recombinant human steroidogenic enzymes 21-hydroxylase, side-chain cleavage and 17a-hydroxylase in Addison s disease and autoimmune polyendocrine syndrome type 111. Ear. J. Endocrinol. 142, 187-194. Simpson, E.R., C. Clyne, G. Rubin, W.C. Boon,... 

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