Aureolic acid group antibiotics

J. Rohr, C. Mendez, and J. A. Salas, The biosynthesis of aureolic acid group antibiotic, Bioorg. Chem., 27 (1998) 41-54. 

Aureolic acid group antibiotics cyclopentanoid antibiotics prostaglandins. 

Aureolic acid group antibiotics, Y16 Aureomycin, Y28 Austamide, KS ... 

Aureolic acid group of antibiotics We have given below an extended summary of the work done with this group of antibiotics, because we have been actively involved in understanding the mode of action of these DNA-binding antibiotics. The summary also illustrates the model example of how different biophysical and biochemical approaches were undertaken to characterize the association of these drugs with chromosomal DNA and the sequential effect of this binding upon the chromatin structure. 

Aureolic acids are a group of tetrahydroanthracene oligosaccharide antibiotics, the name of which is related to their characteristic golden appearance. Members of the aureolic acid group include chromomycin A3, olivomycin A and mithramycin, as the most prominent examples (O Fig. 15). 

Members of this group feature tricyclic carbon framework decorated with two oligosaccharide chains. Mithramycin 48 and chromomycin A3 49 are two aureolic acids that have found their use in cancer chemotherapy. These compounds, interacting with Mg2+, bind GC-rich DNA in a nonintercalative way, and sugar chains are indispensable in stabilizing metal-antibiotic complexes. Carbohydrates are... 

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