Augmented histamine test

Figure 5-3. Dose-response curves of normal subjects in the augmented histamine test. (Adapted from Kay AW. Effect of large doses of histamine on gastric secretion of Hcl An augmented histamine test. Br Med I 2 77-80, 1953.)...

H.O. Hart, P. Madsen, The effect of tetragastrin on gastric acid secretion. Reproducibility and comparison with the pentagastrin test and the augmented histamine test, Scandinavian Journal of Gastroenterology 7 (1972) 171. 

The precise relationship of histamine to acid secretion was firmly established by Andrew Kay of Glasgow, who had developed the augmented histamine test. Mepyramine maleate was used to block the systemic effects of histamine. The ability of histamine to stimulate acid secretion was measured at a dose of 0.1 mg per 10.0 kg of body weight and maximal acid secretion determined in different groups of patients. The dose-response curves for acid secretion in human subjects in response to intravenous infusion of histamine were subsequently determined by Wilfred Card of the Western General Hospital in Edinburgh in conjunction with I. N. Marks. 

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