Atypical tubule hyperplasia

Male rats—and, to a lesser extent, female rats—are also predisposed to developing chronic progressive nephropathy (CPN), and this age-related, spontaneous disease entity appears to convey a slightly increased risk for development of atypical tubule hyperplasia, a preneoplastic lesion, and RTT later in life (Hard 1998, 2002 Seely et al. 2002 Lock and Hard 2004 Hard and Khan 2004). 

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