Atyl Suzuki coupling

Pilot Plant Scale Synthesis of an Atyl-hidole Scale Up of a Suzuki Coupling... 

Coupling Reactions of Areneboronic Acid Derivatives 149 Table3.2 Suzuki coupling of phenylboronic acid with a selection of atyl chlorides. 

A variety of oxetanes are available commercially, and finding appropriate handles (amines, acids, alcohol, etc.) is not difficult. Traditional methods of oxetane synthesis, such as Williamson ether synthesis and [2 + 2] cycloadditions, have been extensively reviewed. Of more interest in the rapid expansion of a monomer collection is the functionalisation of simple oxetanes. For example, atyl oxetanes have been prepared by the nickel catalysed Suzuki coupling of 3-iodooxetane (Scheme 18.20). ... 

Heo Y, Song YS, Kim BT et al (2006) A highly regioselective synthesis of 2-atyl-6-chlorobenzothiazoles employing microwave-promoted Suzuki-Miyaura coupling reaction. Tetrahedron Lett 47 3091-3094... 

The Heck reaction couples a vinylic or an atyl halide with an alkene in the presence of a base (such as triethylamine) and a palladium catalyst (PdL2). Like the Suzuki reaction, the Heck reaction is a substitution reaction the R group of the halide replaces a vinylic hydrogen of an alkene. If there is a substituent attached to the alkene (Z), the R group will be trans to that substituent in the product. Notice that the new C—C bond joins two sp carbons. 

Mixed phosphorus compounds, bearing at least two different tervalent phosphorus moieties have been developed and have found several applications in catalysis. Iri li described the synthesis of aminophosphine-phosphinite ligands 149 and 150, from the commercially available 3-piperidinemethanol and 3-(methylamino) pro-pan-l-ol. Their palladium and platinum complexes 151 and 152, containing metallocyclic rings, were obtained as air-stable compounds with high yields, and characterized by P, and NMR spectroscopy, FTIR spectroscopy and X-ray crystallography. The Pd complexes were effective catalysts on Suzuki-Miyaura cross-coupling reactions of various aryl chlorides and atyl bromides with phe-nylboronic acid. 

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