Atropine like anticholinergic compounds

Although structures with anticholinergic (atropine-like) activities continue to be synthesized and studied, non-anticholinergic spasmolytics also have considerable clinical potential. Mebeverine, a compound of this type, was marketed abroad several years ago it has recently been reported to act by blocking uptake of norepinephrine as well as by a nonspecific depressant effect.Two new series of compounds were synthesized by removal of the alcoholic OH group from the -carbon atom of certain atropine derivatives these compounds retained spasmolytic action, but lacked atropinic "side effects".120 pharmacology of one of these... 

As a class, anticholinergics include the antihistamines, atropine and homatropine anti-Parkinsonian agents like benzotropine, procyclidine, and trihexyphenidyl the antimuscarinics of which atropine is the prototype and antispasmodics like dicyclomine and oxybutymin. Most antimuscarinics are amino-alcohols or their derivatives (usually esters or ethers), aminoamides, or other amines. Antimuscarinics can be divided into two groups. These are the naturally occurring alkaloids and their semisynthetic derivatives like atropine, homatropine, scopolamine, and hyoscyamine and the synthetic amine compounds such as anisotropine, dicyclomine, and ipratropium. 

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